Immunology – Brief Table of Contents

Unit 1: Introduction to Immunology (Detailed Content)

  • 1.1 – Ways of Thinking about Immunology
  • 1.2 – “Health” of the Immune system
  • 1.3 – Challenges Faced by the Immune System
  • 1.4 – A Brief History of Immunology
  • 1.5 – Hematopoiesis
  • 1.6 – Immune System Cells, Tissues, and Organs
  • 1.7 – Communication in the Immune System

Unit 2: The Innate Immune System (Detailed Content)

  • 2.1 – The Complement System
  • 2.2 – Pathogen-Associated Molecular Patterns (PAMPs) and Pathogen Recognition Receptors (PRRs)
  • 2.3 – Inflammation: From Initial Response to Resolution
  • 2.4 – Antiviral Responses

Unit 3: Professional Antigen Presenting Cells (Detailed Content)

  • 3.1 – Different Forms of Engulfment
  • 3.2 – Protein Degradation Pathways Related to Antigen Presentation
  • 3.3 – Genomic Organization and Polymorphisms of the MHC Locus
  • 3.4 – Antigen Processing and Presentation Pathways
  • 3.5 – Professional APC and T Cell Interactions in Lymph Nodes

Unit 4: Development of T Cells and B Cells (Detailed Content)

  • 4.1 – Structure of Lymphocyte Receptors: T-Cell Receptors and B-Cell Receptors
  • 4.2 – Genomic Structure of TCR and BCR Genes
  • 4.3 – V(D)J Recombination
  • 4.4 – Early T-Cell Development
  • 4.5 – TCR Rearrangement and Selection
  • 4.6 – Early B-Cell Development
  • 4.7 – BCR Rearrangement and Selection

Unit 5: Activation and Effector Functions of B-Cell Antibodies and T Cells (Detailed Content)

  • 5.1 – Parsing Signals 2 and 3 During CD4+ T Cell Activation
  • 5.2 – Effector Functions of Helper T Cell Subsets (CD4+)
  • 5.3 – DCs and Helper T Cells Cooperate to Activate CD8+ T-Cells
  • 5.4 – Effector Functions of Cytotoxic T Cells (CD8+)
  • 5.5 – Migration of T Cells to Peripheral Tissues
  • 5.6 – B-Cell Activation following Interaction with Helper T Cells
  • 5.7 – Germinal Centers: Proliferation, Hypermutation, and Class Switching
  • 5.8 – Effector Functions of Different Antibody Classes

Unit 6: Immunological Memory (Detailed Content)

  • Subsets of Memory B Cells and Memory T cells
  • Reactivation of Memory Cells
  • “Boosting” Adaptive Immune Responses
  • Vaccine Designs

Unit 7: Additional Topics

  • Organ Donation
  • Immunotherapies and Immunomodulation
  • Tumor Immunology
  • Type 1 Hypersensitivity
  • Type 2-4 Hypersensitivities
  • Autoimmunity
  • Mucosal Immune Responses
  • Cutaneous Immune Responses
  • Wound Healing Connection to Helminth Infection
  • Innate Immune Receptor Deficiency
  • Chronic Bacterial Infection: Tuberculosis
  • Acquired Immunodeficiency: HIV and AIDS

Unit 8: Immunology-Related Research Techniques

  • Monoclonal and Polyclonal Antibody Production
  • Antibody-Based Research Techniques and Diagnostics
  • Flow Cytometry
  • Animal Use in Immunology Research