Unit 1: Introduction to Immunology (Detailed Content)
- 1.1 – Ways of Thinking about Immunology
- 1.2 – “Health” of the Immune system
- 1.3 – Challenges Faced by the Immune System
- 1.4 – A Brief History of Immunology
- 1.5 – Hematopoiesis
- 1.6 – Immune System Cells, Tissues, and Organs
- 1.7 – Communication in the Immune System
Unit 2: The Innate Immune System (Detailed Content)
- 2.1 – The Complement System
- 2.2 – Pathogen-Associated Molecular Patterns (PAMPs) and Pathogen Recognition Receptors (PRRs)
- 2.3 – Inflammation: From Initial Response to Resolution
- 2.4 – Antiviral Responses
Unit 3: Professional Antigen Presenting Cells (Detailed Content)
- 3.1 – Different Forms of Engulfment
- 3.2 – Protein Degradation Pathways Related to Antigen Presentation
- 3.3 – Genomic Organization and Polymorphisms of the MHC Locus
- 3.4 – Antigen Processing and Presentation Pathways
- 3.5 – Professional APC and T Cell Interactions in Lymph Nodes
Unit 4: Development of T Cells and B Cells (Detailed Content)
- 4.1 – Structure of Lymphocyte Receptors: T-Cell Receptors and B-Cell Receptors
- 4.2 – Genomic Structure of TCR and BCR Genes
- 4.3 – V(D)J Recombination
- 4.4 – Early T-Cell Development
- 4.5 – TCR Rearrangement and Selection
- 4.6 – Early B-Cell Development
- 4.7 – BCR Rearrangement and Selection
Unit 5: Activation and Effector Functions of B-Cell Antibodies and T Cells (Detailed Content)
- 5.1 – Parsing Signals 2 and 3 During CD4+ T Cell Activation
- 5.2 – Effector Functions of Helper T Cell Subsets (CD4+)
- 5.3 – DCs and Helper T Cells Cooperate to Activate CD8+ T-Cells
- 5.4 – Effector Functions of Cytotoxic T Cells (CD8+)
- 5.5 – Migration of T Cells to Peripheral Tissues
- 5.6 – B-Cell Activation following Interaction with Helper T Cells
- 5.7 – Germinal Centers: Proliferation, Hypermutation, and Class Switching
- 5.8 – Effector Functions of Different Antibody Classes
Unit 6: Immunological Memory (Detailed Content)
- Subsets of Memory B Cells and Memory T cells
- Reactivation of Memory Cells
- “Boosting” Adaptive Immune Responses
- Vaccine Designs
Unit 7: Additional Topics
- Organ Donation
- Immunotherapies and Immunomodulation
- Tumor Immunology
- Type 1 Hypersensitivity
- Type 2-4 Hypersensitivities
- Autoimmunity
- Mucosal Immune Responses
- Cutaneous Immune Responses
- Wound Healing Connection to Helminth Infection
- Innate Immune Receptor Deficiency
- Chronic Bacterial Infection: Tuberculosis
- Acquired Immunodeficiency: HIV and AIDS
Unit 8: Immunology-Related Research Techniques
- Monoclonal and Polyclonal Antibody Production
- Antibody-Based Research Techniques and Diagnostics
- Flow Cytometry
- Animal Use in Immunology Research