Mast cells, originating from bone marrow, mature in connective tissues to become fully functional. They contain granules with bioactive molecules and are strategically located in various tissues. While not granulocytes, they share similarities with basophils and play a vital role in allergic responses and immune defense, releasing histamine and other inflammatory mediators.
Category: Immunology
Granulocytes: Rapid Responders That, For Better or Worse, Go on the Fight
Granulocytes, a type of white blood cell, play key roles in the immune system. Neutrophils are effective at combating bacterial and fungal infections, while eosinophils target parasites and allergies. Basophils release chemicals that promote inflammation and allergic responses. Together, they provide rapid immune responses, each with specialized functions in combating different types of pathogens.
Key Players in Regulating the Process of Hematopoiesis
Hematopoiesis, the process of blood cell formation, is regulated by a complex network of molecules and pathways. Key regulators include GATA and Runx transcription factors, Notch and Wnt signaling pathways, cytokines, microRNAs, epigenetic modifications, and specific transcription factors like Pax5 and PU.1. These factors ensure the precise differentiation of diverse blood cell types from stem and progenitor cells.
Life and Biology 