Our laboratory studies E3 ubiquitin ligase enzymes. This video puts these E3 enzymes into the context of the ubiquitin enzyme cascade that consists of E1, E2, and E3 enzymes as well as ubiquitin and target proteins. The goal for our lab is to identify proteins that the E3 enzymes interact with to inform future studies and form hypotheses about the potential functional roles of the proteins we are attempting to characterize.
In this episode, I explain what would typically happen if an organism with a novel trait was released into the wild (it gets diluted out) versus what happens when the novel gene is driven by the CRISPR system (it spreads to all the population).
I discuss embryonic stem cells and the famous 2006 Cell paper showing that differentiated cells can be reprogrammed to be pluripotent stem cells known as iPS cells (induced pluripotent stem cells).
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors: http://www.ncbi.nlm.nih.gov/pubmed/16…