Lymphoid Cells (Immune Cells Part 2)

For Immunology (Chapter 2 Day 2)

1. Immunology nomenclature is replete with acronyms combined with numbers.  What is the background story for clusters of differentiation (CD)?  What are some reasons immunologists may prefer that protein markers be on the surface of the cells rather than in the cytoplasm?
2. Based on the information provided in table 2-3, what CD markers are specific for _________?
   • B cells
   • Th cells
   • Tc cells
   • NK cells
3. Define antigen and then decide whether the following statements are true or false:
   • Each B cell and T cell recognizes a single antigen.
   • Naïve lymphocytes will never recognize an antigen.
   • Memory cells are not generated until the conclusion of a secondary response.
4. Compare and contrast CD4+ T cells with CD8+ T cells in terms of antigen recognition and effector function.
5. What type of Th cells is associated with the following:
   • Helminths (worms)
   • Intracellular pathogens
   • Suppressing an immune response
   • Fungi
6. CD8+ T cells kill cells presenting cognate antigen within MHCI molecules.  How does this differ from NK cell decisions to kill target cells?
7. (Bonus) Write a question about a topic from this reading assignment that you think is important, but that Dr. Graff forgot to cover.