Mechanism of V(D)J Recombination

For Immunology Chapter 7 Day 2

  1. Draw figure 7-5 and then explain why the V and J segments are capable of being recombined in light chains, but not heavy chains, of BCRs.
  2. When two V region segments are joined together, the sequence between the V and J, V and D (as well as D and J segments) are sometimes lost as a circular plasmid.  At other times, the sequence between these segments is inverted.  What is it about the joining of the segments determines the outcome of the intervening sequence?
  3. The five mechanisms that generate antibody diversity in naïve B cells are concisely described on page 239.  Imagine that you are teaching a non-immunology student. Write a paragraph for each mechanism describing how you would teach this material.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

w

Connecting to %s