For Immunology Chapter 7 Day 2
- Draw figure 7-5 and then explain why the V and J segments are capable of being recombined in light chains, but not heavy chains, of BCRs.
- When two V region segments are joined together, the sequence between the V and J, V and D (as well as D and J segments) are sometimes lost as a circular plasmid. At other times, the sequence between these segments is inverted. What is it about the joining of the segments determines the outcome of the intervening sequence?
- The five mechanisms that generate antibody diversity in naïve B cells are concisely described on page 239. Imagine that you are teaching a non-immunology student. Write a paragraph for each mechanism describing how you would teach this material.