Early Thymocyte Development

For Immunology Chapter 9 Day 1

  1. What role(s) does Nothch1 play in early thymocyte development? 
  2. Draw a thymus (figure 2-6d).  Add all of the information from table 9-1 to your drawing. 
  3. Why are thymocytes more likely to develop into αβ T cells than γδ T cells?   
  4. What are some ways in which γδ T cells fall into the innate, rather than adaptive, immunity category? 
  5. Describe the “pre-TCR”.  What happens to immature T cells that signal through their pre-TCR?  (Include RAG protein levels as you answer this question.) 

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