For Immunology Chapter 12 Day 2 Activated B cells depart from their interaction with T cells at the T cell/B cell boundary and head either to the extrafollicular area to immediately begin developing into plasma cells or to the germinal centers (GC) where they go on to interact with FDC and TFH. Explain which activated … Continue reading B Cell Life after Split with T Cell

For Immunology Chapter 12 Day 1 What were some of the important ideas MacFarlane Burnett put forth in this “Clonal Selection Theory” publication? When B cells interact with CD4+ T cells that recognize the same antigen, there are three signals. Describe signals 1, 2, and 3 as well as the purpose of each of these … Continue reading B Cells Meet T Cells in the Middle

For Immunology Chapter 11 Day 1 “Signal 1” occurs when a TCR recognizes antigen within an MHC molecule on an antigen presenting cell. Then, transcription of IL-2 and CD25 occur.  What is the significance of the upregulation in these two genes? What molecular interactions would you expect to find in cSMACs and pSMACs? What purpose … Continue reading T Cell and APC Signals 1, 2, and 3!