For Immunology Chapter 9 Day 3 During the selection process in the thymus, thymocytes mature from CD4+ CD8+ (DP) cells to being single positive (SP) for either CD4 or CD8. Briefly describe the following: Instructive model Stochastic (random) model The kinetic signaling model is the currently accepted idea for explaining why cells commit to a … Continue reading Wrapping Up T Cell Development with a Discussion of Death (or Not)

For Immunology Chapter 9 Day 2 After jumping through the hoops necessary to make functional α and β chains of their TCRs, ~95% of CD4+CD8+ (DP) thymocytes die from what? Because of this fact, why are quotes necessary when someone says thymocytes “learn” or are “educated” in the thymus? What stages of T-cell development (DN1, … Continue reading T Cell Development – Selection and More Selection

For Immunology Chapter 9 Day 1 What role(s) does Nothch1 play in early thymocyte development?  Draw a thymus (figure 2-6d).  Add all of the information from table 9-1 to your drawing.  Why are thymocytes more likely to develop into αβ T cells than γδ T cells?    What are some ways in which γδ T cells fall into the innate, rather than … Continue reading Early Thymocyte Development