A Tale of Leishmania Immunity in Multiple NLRP10 Knockout Mice

Congratulations to my friend and co-worker for many years, Gwen Clay.   This week an interesting study was published in the Journal of Immunology evaluating the role of a protein in the NOD-like receptor family (NLRP10) during cutaneous leishmaniasis.  Gwen and I had countless discussions about data interpretation that were made all the more complicated upon the discovery that the first transgenic line harbored a second mutation (DOCK8).  Thanks also go out to the many co-authors on this paper, especially Mary and Diogo, that saw this study through to its conclusion by performing the necessary follow-up experiments in additional lines of mice.

 

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