Chapter 1 Day 1
- In what ways are immunity and vaccination closely related?
- What characteristic of rabies infection allows for the vaccination to be efficacious even though the person has already been infected? How was the rabies vaccine prepared? (The answers to these questions are not fully answered in the book.)
- No vaccine is 100% effective, so how was smallpox eradicated?
- In what ways does the immune system provide benefits beyond protection against infectious diseases?
- Pepsi is clearly better than Coke. However, the relative importance of humoral and cellular immunity was a heated debate. Who were the major proponents of each immunological branch? What was the supporting evidence for each side? Who won the argument?
- Compare and contrast selective theory with instructional theory. How did the clonal selection theory extend upon the selective theory?
Chapter 1 Day 2
- Commensal bacteria live on our bodies (e.g. on skin) and in our bodies (e.g. mucosal surfaces). These bacteria typically do not cause pathology. When might they cause pathology and why? (Hint: Location, location, location…)
- The “3 Big Challenges” of immunity are specificity, tolerance, and appropriateness. The final challenge hints that immune responses can vary depending on the nature of the problem. Discuss the lifestyle differences of various infectious diseases. What T cell type is associated with intracellular pathogens? Extracellular pathogens? (Warning: There are many caveats and exceptions to these T cell/pathogen associations.)
- Taking a step back, we will take a look at tolerance, the ability of the immune system to ignore non-dangerous commensal organisms and, perhaps more importantly, the body of the organism with the immune system. Discuss the “Danger Hypothesis”.
- Compare and contrast innate and adaptive immunity. Which branch commonly uses receptors encoded in the germline? …receptors that are randomly generated
- How is adaptive immunity linked to immunological memory? What does this have to do with vaccines?
- Discuss the following:
- Hypersensitivity reactions
- Autoimmune diseases
- Immune deficiency
- Compare and contrast immune responses to cancer and to transplanted organs. What is the cause of immunodeficiency in these two different situations?