For Immunology (Chapter 3 Day 3)
- What types of molecules have immunoglobulin domains? The allowance for the loosely folded loops between beta-strands of the Ig domain to acquire different sequences is important for BCRs and TCRs. Discuss this property with a focus on “CDRs”.
- Draw the antibody (large is good!) as shown in figure 3-20. Add additional labels as are mentioned in figure 3-21. Summarize the functions of all of the labeled parts.
- Why does the heavy chain of an antibody determine the antibody’s “class”? Summarize the structural features of the different classes and subclasses of antibodies.
- Which classes are membrane bound and which classes are secreted? Discuss the feature(s) that determine whether the antibody will remain surface bound (as a BCR) or secreted.
- What region of an antibody is bound by anti-Fab, anti-Fc, anti-isotype, anti-allotype, and anti-idiotype antibodies? Explain your answer as if you were talking to someone that you had just taught antibody structure to. (In other words, the descriptions in Table 3-3 seem rather technical. Dumb it down for me.)
- Compare and contrast the signaling pathways downstream of the BCR and the TCR. (This answer should summarize many pages in the book, so it could easily be lengthy.)