Topic: Antibody somatic recombination, also known as VDJ recombination, which occurs in B-cells.
Two recombination events: The process involves two somatic recombinations: one in the heavy chain and another in the light chain.
Heavy chain VDJ recombination: The heavy chain gene consists of a leader segment, a variable region, a diversity segment, a joining segment, and a constant region, which will ultimately make the heavy chain of the antibody.
Light chain VJ recombination: The light chain gene, on the other hand, consists of a variable segment, a joining segment, and a constant segment, which will ultimately make the light chain protein.
Antibody proteins contain both heavy and light chains: After the two somatic recombinations, the genes are transcribed into RNA, spliced to remove introns, and translated into proteins, resulting in the production of a unique antibody that binds to a specific antigen.