Joel Graff, Ph.D.

20161005_145501 Joel W. Graff

Department of Biology

Montana Tech of The University of Montana

1300 West Park Street

Butte, MT 59701

jgraff(at)mtech.edu

Professional Preparation:

  • Ph.D. -Veterinary Molecular Biology, Montana State University, August 2008
  • B.S. Biotechnology, Montana State University, May 2001
  • Biology, Montana State University, May 2001
  • Biochemistry minor, Montana State University, May 2001

Appointments:

  •  Assistant Professor: Montana Tech of the University of Montana (January 2016-Present)
  • Research Assistant Professor: University of Iowa (November 2013-January 2016)
  • Research Health Science Specialist: Iowa City VAMC (August 2008-January 2016)
  • Assistant Research Scientist: University of Iowa (October 2010-September 2012)
  • Postdoctoral Fellow: University of Iowa (August 2008-September 2010)
  • Doctoral Student: Montana State University (September 2004-August 2008)
  • Research Associate: Montana State University (September 2001-August 2004)
  • Undergraduate Researcher: Montana State University (June 1999-May 2001)

Courses Taught

Blog Posts

  • HHMI001 – Collecting Environmental Samples
  • HHMI002 – Phage Enrichment for Isolation (Direct Isolation, too)

Publications (external link to PubMed)

  1. Sudan, B., Wacker, M.A., Wilson, M.E., Graff, J.W. A systematic approach to identify markers of distinctly activated human macrophages. 2015. Front Immunol. 6(253):1-18. PMID 26074920.
  2. Eigsti R.L., Sudan B., Wilson M.E., Graff J.W. Regulation of activation-associated microRNA accumulation rates during monocyte-to-macrophage differentiation. J Biol Chem. 2014 Aug 22 (Epub ahead of print). PMID 25148686.
  3. Novais F.O., Carvalho L.P., Graff J.W., Beiting D.P., Ruthel G., Roos D., Betts, M.R., Goldschmidt M.H., Wilson M.E., de Oliviera C.I., Scott P. Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. PLoS Pathogens. 2013: 9(7):e1003504. PMID 23874205.
  4. Graff J.W., Powers L.S., Dickson A.M., Kim J., Hassan I.H., Kremens K., Gross T.J., Wilson M.E., Monick M.M. Cigarette smoking decreases global microRNA expression in human alveolar macrophages. PLoS One. 2012:7(8)e44066. PMID 22952876.
  5. Graff J.W., Dickson A.M., Clay G., McCaffrey A.P., Wilson M.E. Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem. 2012 Jun 22; 287(26):21816-25. PMID 22549758.
  6. Wendlandt E.B., Graff J.W., Gioannini T.L., McCaffrey A.P., Wilson M.E. The role of microRNAs miR-200b and miR-200c in TLR4 Signaling and NF-κB Activation. Innate Immun. 2012 April 20; 18(6):846-55 PMID 22522429.
  7. Daughenbaugh K.F., Graff J.C., Hedges J.F., Graff J.W., Holderness J., Jutila M.A. Induced cytokine mRNA stability: A mechanism for rapid gd T cell responses to oligomeric procyanidins. Genes Immun. 2011 12(5):378-89. PMID 21307878
  8. Thalhofer C.J., Graff J.W., Love-Homan L., Hickerson S.M., Craft N., Beverley S.M., Wilson M.E.  In vivo Imaging of Transgenic Leishmania Parasites in a Live Host. J Vis Exp. 27(41). pii: 1980. doi: 10.3791/1980, 2010. PMID: 20689512.
  9. Graff J.W., Ettayebi K., Hardy M.E. Rotavirus NSP1 inhibits NFkB activation by inducing proteasome-dependent degradation of b-TrCP: A novel mechanism of IFN antagonism. PLoS Pathogens. 2009. 5:e1000280. PMID 19180189.
  10. Graff J.W., Ewen J., Ettayebi K., Hardy M.E. Zinc-binding domain of rotavirus NSP1 is required for proteasome-dependent degradation of IRF3 and autoregulatory NSP1 stability. J Gen Virol. 2007, 88: 613-620. PMID: 17251580.
  11. Shaneyfelt M.E., Burke A.D., Graff J.W., Jutila M.A., Hardy M.E. Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay. Virol J. 2006, 3:68. PMID: 16948846.
  12. Lochridge V.P., Jutila K.L., Graff J.W., Hardy M.E. Epitopes in the P2 domain of norovirus VP1 recognized by monoclonal antibodies that block cell interactions. J Gen Virol. 2005, 86:2799-2806. PMID: 16186235.
  13. Graff J.W., Mitzel D.N., Weisend C.M., Flenniken M.L., Hardy M.E. Interferon regulatory factor 3 is a cellular partner of rotavirus NSP1. J Virol. 2002, 76:9545-9550. PMID: 12186937.