For Immunology Chapter 5 Day 3
- Acute infections start out by using positive feedback loops to ramp up the level of inflammation. Summarize this response starting with the initial problem (example: septicemia) and following through to acute phase proteins.
- We will skip NK cells for now and come back to them in Chapter 13.
- There are numerous negative feedback mechanisms to put an end to the positive feedback that ramps up an inflammatory response. Briefly discuss each of the following:
- Shortened MyD88 isoform
- IκB family members
- To my knowledge, alum is the only approved adjuvant for use in humans. How does the lack of variety in adjuvants hinder the development of vaccines for certain types of infectious diseases? (Hint: Think helper T cell differentiation.)