For Immunology Chapter 5 Day 3 Acute infections start out by using positive feedback loops to ramp up the level of inflammation.  Summarize this response starting with the initial problem (example: septicemia) and following through to acute phase proteins.  We will skip NK cells for now and come back to them in Chapter 13.  There are numerous … Continue reading Appropriate Immune Responses via Regulation of Innate Immunity

For Immunology Chapter 5 Day 2 Jules Hoffman and Bruce Beutler share ½ of the Nobel Prize in 2011.  Summarize their research.  Most TLRs can be found either at the plasma membrane to detect extracellular ligands or at endosomes/lysosomes to detect ingested ligands.  TLR4 is unique because it can be found in both compartments.  TLR4, like many … Continue reading Pattern Recognition Receptors and Interferon-Induced Antiviral Immunity

For Immunology Chapter 5 Day 1 There are a number of proteins and peptides with antimicrobial properties that are produced on skin and mucosal surfaces.  Be prepared to teach the other students in the class about: Lysozyme and lactoferrin  S100 proteins and defensins  Surfactant proteins and cathelicidin   What sort of problems would a mutation in CD91 presumably cause?  … Continue reading Intro to Innate Immunity