For Immunology (Chapter 3 Day 3) What types of molecules have immunoglobulin domains? The allowance for the loosely folded loops between beta-strands of the Ig domain to acquire different sequences is important for BCRs and TCRs.  Discuss this property with a focus on “CDRs”. Draw the antibody (large is good!) as shown in figure 3-20. … Continue reading Antibody Structure and BCR/TCR Signaling

For Immunology (Chapter 3 Day 2)  TCRs and BCRs lack intracellular domains that are capable of signaling.  How do these receptors signal downstream?  (Your answer should include discussion of ITAMs, kinases, lipid rafts, tyrosines, coreceptors, SH2 domains, etc.)  Discuss how Src kinases are regulated and why it is important to have more than one layer of regulation.  Also, … Continue reading Signaling: Common Pathways and Strategies

For Immunology (Chapter 3 Day 1) Describe interactions between ligands and receptors.  (Use the following words: association constant, dissociation  constant, multivalent, affinity, avidity, “On”, “Off”, van der Waals, hydrogen bonds, hydrophobic interactions) What is an MTOC?  How is an MTOC associated with cytokine concentrations?  Discuss signal transduction pathways.  Who are the main players in these pathways? … Continue reading Receptor-Ligand Interactions